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To pursue his acting career, he headed to Los Angeles, California, in a pickup truck borrowed from his stepfather. When he arrived in Los Angeles, he could only drive during the day because the truck had two broken headlights. Eads got his big break on the primetime soap opera Savannah. Though his character died in the pilot episode, Eads was so popular that producers continued to use him via flashbacks and eventually brought him back as the character's identical twin.

Afterwards, Eads guest-starred on ER, and worked on several made-for television films like Crowned and Dangerous with Yasmine Bleeth in 1997.

In 2000 Eads became one of the lead characters of the CBS series CSI, in which he portrays a Las Vegas forensic scientist called Nick Stokes.

Parallel to , Eads has worked on some more made-for television films, such as 2003 Monte Walsh, with Isabella Rossellini, and 2004 Evel Knievel, where he played Evel Knievel.

(wikipedia.org)