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Reyes had a short stint on The Sopranos as the girlfriend of Paulie Walnuts.She also made a brief appearance on the American television series Oz, where she played the wife of the blinded Correctional Officer Eugene Rivera. She has also starred in The Fuzz Show as Girl #1.

She is best known for her portrayal of Nurse Carla Espinosa on the NBC sitcom Scrubs from 2001-present. "I really admire Carla - she's smart and sassy and a very good nurse," says Reyes. "I like that she remains confident and unapologetic in a world where nurses don't receive the same respect as doctors."

Reyes' other film credits include Martin Scorsese's Bringing Out the Dead, and the independent film Went to Coney Island on a Mission from God, Be Back by Five. She can also be seen in the film Washington Heights. Additionally Reyes acted in and co-produced (with her husband, writer/director Edwin M. Figueroa) Taino, a short film which was screened at the 1999 New York International Latino Film Festival and at the 2001 Los Angeles Latino Film Festival.

Reyes' television credits include 100 Centre Street. Her made-for-television movies include John Sanford's Mind Prey, with Eriq La Salle, and The Prosecutors.

(wikipedia.org)