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Her acting career began in 1992 with the TV movie Quicksand: No Escape. Her role as Maureen McCormick in the 2000 TV movie Growing Up Brady brought her much attention, as well as a role on the CBS sitcom Ladies Man. In 2004, in addition to her role on 8 Simple Rules she has had starring roles on the NBC miniseries 10.5, on the ABC Family original movie Crimes of Fashion, and in the independent film Debating Robert Lee.

Cuoco was named #75 on FHM-US's 100 Sexiest Women in 2004. She began voicing the character of Brandy Harrington on the Disney Channel's cartoon, Brandy and Mr. Whiskers, later in 2004. Recently, Kaley has lent her voice for Elena Potato, a main character on the Kids' WB, Disney Channel Asia show, Monster Allergy.

Cuoco appeared as Billie Jenkins, a new witch that was searching for her lost sister in the 8th season of the hit TV show Charmed along side Holly Marie Combs, Alyssa Milano and Rose Mcgowan and remained until the series was ended. In 2004, Cuoco co-starred in the movie The Hollow with stars Nick Carter and Kevin Zegers.

Kaley has also starred in the recent Lifetime movie To Be Fat Like Me which premiered on January 8, 2007.[1] She played a minor role in the Prison Break episode "The Message", and in the subsequent episode "Chicago."

Kaley currently stars on the new CBS sitcom, The Big Bang Theory, which debuted September 24, 2007.

(wikipedia.org)