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McKidd's first professional role was in the television series Father Ted; he played Father Deegan in the 1996 episode "A Christmassy Ted". Some of his subsequent roles include Tommy in Trainspotting and Malky Johnson in Small Faces, with Iain Robertson. In 2004, he played James Hepburn, 4th Earl of Bothwell, the third husband of Mary, Queen of Scots, in the BBC mini-series Gunpowder, Treason & Plot.

He appeared in Kingdom of Heaven, the blockbuster movie directed by Ridley Scott, the 2002 film adaptation of Nicholas Nickleby and was also the voice of Jezz Torrent in GTA: Vice City. Others might know him from Neil Marshall's horror film, Dog Soldiers, as Pte. Cooper. In the 2005 BBC drama, The Virgin Queen, he played Thomas Howard, 4th Duke of Norfolk.

In 1998, he again joined Robert Carlyle on-screen in the 4-part BBC2 series Looking After Jo Jo, playing the role of Basil, a drug dealing cohort of Carlyle's eponymous character. The show was directed by John Mackenzie of The Long Good Friday. He was one of the stars of the joint HBO/BBC series Rome, where his portrayal of the soldier/politician Lucius Vorenus received critical acclaim.

Additional work includes his role in the Silence of the Lambs prequel Hannibal Rising (2007). Starting in the fall of 2007, McKidd stars in the American science-fiction television series Journeyman on NBC.

(wikipedia.org)