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From 1998-2000 Krause portrayed the character Casey McCall on the ABC comedy Sports Night, created by his friend Aaron Sorkin. Although the show received considerable critical acclaim, it struggled to find an audience and was cancelled after two seasons.

Krause starred in the series Six Feet Under in 2001 and received much critical acclaim and several award nominations (including three Emmy nominations) for his portrayal of funeral director Nate Fisher.

In December 2006 he played the lead role, Detective Joe Miller, in the Sci Fi Channel miniseries The Lost Room.

He is currently starring in ABC's new drama Dirty Sexy Money alongside veteran actor Donald Sutherland.

(wikipedia.org)