Gregory House is a maverick medical genius, who heads a team of young diagnosticians at the fictional Princeton-Plainsboro Teaching Hospital in New Jersey. Most episodes start with a cold open somewhere outside the hospital, showing the events leading to the onset of symptoms for that week's main patient. The episode follows the team in their attempts to diagnose and treat the illness.
The team arrives at diagnoses using the Socratic method and differential diagnosis, with House guiding the deliberations. House often discounts the information and opinions from his underlings, pointing out that their contributions have missed various relevant factors. The patient is usually misdiagnosed two or three times over the course of each episode, often with sarcoidosis, lupus, cancer, or an infection, and treated with medications appropriate to those diagnoses that cause further complications. Often the ailment cannot be easily deduced because the patient has lied about symptoms and circumstances. House frequently mutters, "Everybody lies," or proclaims during the team's deliberations: "The patient is lying," or "The symptoms never lie." Even when not stated explicitly, this assumption guides House's decisions and diagnoses. (wikipedia.org)