Born and raised in Trenton, Michigan, Rajskub latr moved to Los Angeles where she became one of the original cast members of Mr. Show, and also had roles on The Larry Sanders Show, Shasta McNasty, Veronica's Closet, the US version of The Sketch Show, News Radio, and 24.

She has since appeared in more dramatic roles, most notably her role as CTU tech analyst Chloe O'Brian on 24, which she joined in 2003 at the start of the show's third season. Her character was a hit with viewers and critics and was one of the few cast members to return in the show's fourth season. After being a regular guest star for two seasons, Rajskub became a main cast member in the show's fifth season. She is now lead female, with top billing second only to Kiefer Sutherland.

She also appeared in Kelsey Grammer's The Sketch Show on Fox Television, King of Queens as a character named "Priscilla", a waitress at a pirate-themed kiddie restaurant in an episode of Newsradio ("The Secret of Management"), and in numerous films including Serial Slayer (aka Claustrophobia), Mysterious Skin, Legally Blonde 2, Sweet Home Alabama, Dude, Where's My Car?, Man on the Moon, Punch-Drunk Love, The Anniversary Party, Firewall, Little Miss Sunshine, Weezer's music video for their song The Good Life, as well as portraying a blind girl in the film Road Trip.

(wikipedia.org)